GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs7246967 | 1 | rs7246967 | chr19:23056346 | ZNF492 | chr19:22817126-22850472:+ | -0.5 | -5.66 | 1.61E-7 | Bronchopulmonary dysplasia |
| THYM | cis | rs9876781 | 1 | rs725309 | chr3:48418708 | TREX1 | chr3:48501186-48509043:+ | 0.28 | 4.49 | 2.0E-5 | Longevity |
| THYM | cis | rs9876781 | 1 | rs725310 | chr3:48418571 | TREX1 | chr3:48501186-48509043:+ | 0.3 | 4.76 | 6.81E-6 | Longevity |
| THYM | cis | rs10416265 | 1 | rs7254758 | chr19:33608047 | GPATCH1 | chr19:33571786-33621318:+ | 0.37 | 4.33 | 3.69E-5 | Bone properties (heel) |
| THYM | cis | rs4803480 | 1 | rs7255679 | chr19:42063981 | CEACAM21 | chr19:42055886-42093196:+ | 0.67 | 8.85 | 4.68E-14 | Schizophrenia |
| THYM | cis | rs10416265 | 1 | rs7255968 | chr19:33601902 | GPATCH1 | chr19:33571786-33621318:+ | 0.37 | 4.23 | 5.32E-5 | Bone properties (heel) |
| THYM | cis | rs7246967 | 1 | rs7257127 | chr19:23056699 | ZNF492 | chr19:22817126-22850472:+ | -0.5 | -5.66 | 1.61E-7 | Bronchopulmonary dysplasia |
| THYM | cis | rs7565981 | 1 | rs72627410 | chr2:101427758 | PDCL3 | chr2:101179418-101193201:+ | 0.51 | 4.17 | 6.67E-5 | Creutzfeldt-Jakob disease (variant) |
| THYM | cis | rs12220777 | 1 | rs72644213 | chr10:81783660 | LOC219347 | chr10:81805991-81838949:- | 0.63 | 4.28 | 4.47E-5 | Chronic obstructive pulmonary disease-related biomarkers |
| THYM | cis | rs58749629 | 1 | rs7270354 | chr20:44607661 | WFDC3 | chr20:44402847-44420547:- | -0.55 | -4.16 | 7.09E-5 | Abdominal aortic aneurysm |
| THYM | cis | rs9976767 | 1 | rs7278547 | chr21:43835827 | TMPRSS3 | chr21:43791996-43816200:- | 0.51 | 4.61 | 1.25E-5 | Type 1 diabetes |
| THYM | cis | rs17761864 | 1 | rs72819593 | chr17:2199489 | SRR | chr17:2207248-2228553:+ | -0.55 | -5.52 | 2.92E-7 | Esophageal cancer (squamous cell) |
| THYM | cis | rs1930961 | 1 | rs7285549 | chr22:25874580 | CRYBB2 | chr22:25615612-25627836:+ | 1.12 | 7.51 | 3.14E-11 | Bipolar disorder with mood-incongruent psychosis |
| THYM | cis | rs17396122 | 1 | rs72872744 | chr2:48704719 | FOXN2 | chr2:48541795-48606434:+ | 0.28 | 4.22 | 5.49E-5 | Schizophrenia |
| THYM | cis | rs2463822 | 1 | rs72921498 | chr11:62113090 | ASRGL1 | chr11:62104774-62160885:+ | -0.62 | -6.56 | 2.77E-9 | Chronic obstructive pulmonary disease-related biomarkers |